PACS1 Rabbit Polyclonal Antibody

CAT#: TA349175

Rabbit Polyclonal Anti-PACS1 Antibody

Product Images

Western blot analysis of PACS1 in rat bladder tissue lysate with PACS1 antibody at 1 ug/mL.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: PACS1 antibody was raised against a 17 amino acid peptide near the center of human PACS1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: PACS1 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 106 kDa; Observed: 105 kDa
• Gene Name: phosphofurin acidic cluster sorting protein 1
• Database Link:
  NP_060496
  Entrez Gene 55690 Human
  UniProt ID Q6VY07
• Background: The phosphofurin acidic cluster sorting protein 1 (PACS1), belongs to the PACS family of cytosolic connector proteins that localize different membrane proteins to the trans-Golgi network (TGN) (1,2). Mutations in PACS1 cause defects in cranial-neural crest migration during early development, leading to a recognizable intellectual disability syndrome (3). PACS1, along with the related protein PACS2, also plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance (4).
• Synonyms: hfzo1; hfzo2