KLF17 Rabbit Polyclonal Antibody

CAT#: TA349122

Rabbit Polyclonal Anti-KLF17 Antibody

Product Images

Western blot analysis of KLF17 in rat liver tissue lysate with KLF17 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of KLF17 in mouse liver tissue with KLG17 antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: KLF17 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human KLF17.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: KLF17 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 28, 39, 43 kDa; Observed: 38 kDa
• Gene Name: Kruppel-like factor 17
• Database Link:
  NP_775755
  Entrez Gene 128209 Human
  UniProt ID Q5JT82
• Background: KLF17, also known as ZNF393, is a member of the Sp/KLF family of transcription factors (1,2). KLF17 binds to the promoter and negatively regulates the transcription of Id-1, a key metastasis regulator in breast cancer (3). Suppression of KLF17 promotes breast cancer cell invasion and epithelial-mesenchymal transition (3). Down-regulated KLF17 expression is also associated tumor invasion and poor prognosis in hepatocellular carcinoma, suggesting that the level of KLF17 expression can serve as a prognostic indicator (4).
• Synonyms: H3; insl7; RXN3; ZINS4