KIBRA (WWC1) Rabbit Polyclonal Antibody

CAT#: TA349110

Rabbit Polyclonal Anti-WWC1 Antibody

Product Images

Western blot analysis of WWC1 in human brain tissue lysate with WWC1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of WWC1 in mouse brain tissue with WWC1 antibody at 5 ug/mL.

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  Immunofluorescence of WWC1 in mouse brain tissue with WWC1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: WWC1 antibody was raised against an 18 amino acid peptide near the amino terminus of human WWC1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: WWC1 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 123 kDa; Observed: 110 kDa
• Gene Name: WW and C2 domain containing 1
• Database Link:
  NP_001155133
  Entrez Gene 23286 Human
  UniProt ID Q8IX03
• Background: The WW and C2 domain containing 1 (WWC1) protein, also known as KIBRA, possesses two WW domains and an internal C2-like domain (1). WWC1 was originally identified as a memory performance-associated protein in humans (2) and has recently been shown to be a novel regulator of the Hippo pathway (3). WWC1 is phosphorylated by the mitotic kinases Aurora-A and ?? (4), and in turn activates the Aurora kinases and is required for precise chromosome alignment during mitosis (5).
• Synonyms: PACS-2; PACS1L