UVRAG Rabbit Polyclonal Antibody

CAT#: TA349093

Rabbit Polyclonal Anti-UVRAG Antibody

Product Images

Western blot analysis of UVRAG in mouse lung tissue lysate with UVRAG antibody at 1 ug/mL.

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  Immunohistochemistry of UVRAG in human lung tissue with UVRAG antibody at 5 ug/mL.

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  Immunofluorescence of UVRAG in human lung tissue with UVRAG antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: UVRAG antibody was raised against an 18 amino acid peptide near the carboxy terminus of human UVRAG.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: UVRAG antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 77 kDa; Observed: 75 kDa
• Gene Name: UV radiation resistance associated
• Database Link:
  NP_003360
  Entrez Gene 7405 Human
  UniProt ID Q9P2Y5
• Background: The class III type phosphoinositide 3-kinase (PI3KC3) / Vps34 regulates vacuolar trafficking as well as autophagy (1). UVRAG (UV radiation resistance-associated gene) is associated with the Beclin-1/PI3KC3 complex and promotes PI3KC3 enzymatic activity and autophagy, while suppressing proliferation (2). UVRAG is highly expressed in brain, lung, kidney and liver and contains one C2 domain, which is involved in calcium-dependent phospholipid binding. Beclin-1 binding to UVRAG promotes both autophagosome maturation and endocytic trafficking (3). UVRAG is also a potential tumor suppressor protein with frameshift mutations observed in colon and gastric carcinomas (4,5).
• Synonyms: alpha 2; alpha 3c; bA408E5.3; TUBA2; tubulin