HDAC6 Rabbit Polyclonal Antibody

CAT#: TA349074

Rabbit Polyclonal Anti-HDAC6 Antibody

Product Images

Western blot analysis of HDAC6 in human testis tissue lysate with HDAC6 antibody at (A) 0.5 and (B) 1 ug/mL.

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  Immunohistochemistry of HDAC6 in human testis tissue with HDAC6 antibody at 5 ug/mL.

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  Immunofluorescence of HDAC6 in human testis tissue with HDAC6 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.5 - 1 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: HDAC6 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human HDAC6
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: HDAC6 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 134 kDa; Observed: 145 kDa
• Gene Name: histone deacetylase 6
• Database Link:
  NP_006035
  Entrez Gene 15185 MouseEntrez Gene 10013 Human
  UniProt ID Q9UBN7
• Background: The histone deacetylase (HDAC) family contains multiple members which are divided into four classes. Class II of the HDAC family comprises six members, HDAC4, 5, 6, 7, 9 and 10, each of which appear to have tissue-specific roles (1). HDAC6 contains an internal duplication of two catalytic domains which appear to function independently of each other (2). HDAC6 has been shown to be part of the microtubule network and acts as a specific alpha-tubulin deacetylase, and has been suggested to be a potential therapeutic target in neurodegenerative disease (3).
• Synonyms: CMT2A; CMT2A2; CMT2A2A; CMT2A2B; CPRP1; HMSN6A; HSG; MARF

Reference Data

• Protein Families: Druggable Genome, Transcription Factors