GABARAPL2 Rabbit Polyclonal Antibody

CAT#: TA349071

Rabbit Polyclonal Anti-GABARAPL2 Antibody

Product Images

Western blot analysis of GABARAPL2 in human brain tissue lysate with GABARAPL2 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunohistochemistry of GABARAPL2 in rat brain tissue with GABARAPL2 antibody at 5 ug/mL.

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  Immunofluorescence of GABARAPL2 in rat brain tissue with GABARAPL2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: GABARAPL2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human GABARAPL2.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: GABARAPL2 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 13 kDa; Observed: 13 kDa
• Gene Name: GABA type A receptor associated protein like 2
• Database Link:
  NP_009216
  Entrez Gene 11345 Human
  UniProt ID P60520
• Background: Gamma-aminobutyric acid (GABA) is the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing in the central nervous system (1). It has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC (2). GABARAPL2 (GABAA receptor-associated protein-like 2), also known as GATE16, was initially identified as a membrane transport modulator and is a mammalian ortholog to the autophagy protein ATG8 (3,4). It is thought that GABARAPL2 and other members of the ATG8 family act as scaffolds for assembly of the Unc-51 like kinase (ULK) complex in the formation of autophagosomes (5).
• Synonyms: CT73; svph1