OASL Rabbit Polyclonal Antibody

CAT#: TA349046

Rabbit Polyclonal Anti-OASL Antibody

Product Images

Western blot analysis of OASL in mouse bladder tissue lysate with OASL antibody at 1 ug/mL.

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  Immunocytochemistry of OASL1 in HepG2 cells with OASL1 antibody at 2.5 ug/mL.

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  Immunofluorescence of OASL1 in HepG2 cells with OASL1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: OASL antibody was raised against a 17 amino acid peptide near the amino terminus of human OASL.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: OASL antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 57 kDa; Observed: 65 kDa
• Gene Name: 2'-5'-oligoadenylate synthetase like
• Database Link:
  NP_003724
  Entrez Gene 8638 Human
  UniProt ID Q15646
• Background: OASL (2'-5'-oligoadenylate synthetase-like), also known as p59OASL or TRIP14 (thyroid receptor-interacting protein 14), is a 514 amino acid protein that exists as two alternatively spliced isoforms, designated p56 and p30, and contains two ubiquitin-like domains (1). It is widely expressed in a variety of tissues and interacts with the ligand binding domain of the thyroid receptor (TR) and is able to bind double-stranded RNA and DNA, possibly playing a role in RNA degradation and the overall inhibition of protein synthesis (2-3). Methyl CpG-binding protein 1 (MBD1), which functions as a transcriptional repressor, was identified as a strong p59 OASL interactor (4).
• Synonyms: DRP; DRP1; SMAP-3