CLOCK Rabbit Polyclonal Antibody

CAT#: TA347532

Rabbit Polyclonal Anti-Clock Antibody

Product Images

Western blot analysis on HuvEc cell lysate using Clock Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:3000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-Clock Antibody: A synthesized peptide derived from human Clock
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Affinity-chromatography
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 95 kDa
• Gene Name: clock circadian regulator
• Database Link:
  NP_004889
  Entrez Gene 12753 MouseEntrez Gene 60447 RatEntrez Gene 9575 Human
  UniProt ID O15516
• Background: CLOCK ARNTL/2-CLOCK heterodimers activate E-box element (3'- CACGTG-5') transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression. Acetylates primarily histones H3 and H4.
• Synonyms: bHLHe8; KAT13D
• Note: Clock antibody detects endogenous levels of total Clock

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Circadian rhythm - mammal