Presenilin 1 (PSEN1) Rabbit Polyclonal Antibody

CAT#: TA347463

Rabbit Polyclonal Anti-Presenilin 1 Antibody

Product Images

Western blot analysis on RAW264.7 cell lysate using Presenilin 1 Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-Presenilin 1 Antibody: A synthesized peptide derived from human Presenilin 1
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Affinity-chromatography
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 60 kDa
• Gene Name: presenilin 1
• Database Link:
  NP_000012
  Entrez Gene 5663 Human
  UniProt ID P49768
• Background: PSEN1 probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Regulates epithelial- cadherin function.
• Synonyms: AD3; FAD; PS-1; PS1; S182
• Note: Presenilin 1 antibody detects endogenous levels of total Presenilin 1

Reference Data

• Protein Families: Druggable Genome, Protease, Transmembrane
• Protein Pathways: Alzheimer's disease, Neurotrophin signaling pathway, Notch signaling pathway, Wnt signaling pathway