TORC1 (CRTC1) Mouse Monoclonal Antibody [Clone ID: 3D7-E5-D9]

CAT#: TA346923

Mouse Monoclonal MECT1 / Torc1 Antibody

Specifications

Product Data

• Clone Name: 3D7-E5-D9
• Applications: FC, IF, IP, WB
• Recommended Dilution: WB: 1:1000, IF: 1:300, FC: 1:100
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: The immunogen for CRTC1 antibody: purified recombinant human MECT1 / Torc1 protein fragments expressed in E.coli.
• Formulation: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 78 kDa
• Gene Name: CREB regulated transcription coactivator 1
• Database Link:
  NP_056136
  Entrez Gene 23373 Human
  UniProt ID Q6UUV9
• Background: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses (By similarity)
• Synonyms: MECT1; TORC-1; TORC1; WAMTP1

Reference Data

• Protein Families: Transcription Factors