CHD3 Mouse Monoclonal Antibody [Clone ID: 7F6-G2-E5]

CAT#: TA346916

Mouse Monoclonal CHD3 (C-terminus) Antibody

Specifications

Product Data

• Clone Name: 7F6-G2-E5
• Applications: IF, IP, WB
• Recommended Dilution: WB: 1:1000, IF: 1:400
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: The immunogen for CHD3 antibody: purified recombinant human CHD3 (C-terminus) protein fragments expressed in E.coli.
• Formulation: ascites
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 260 kDa
• Gene Name: chromodomain helicase DNA binding protein 3
• Database Link:
  NP_001005271
  Entrez Gene 216848 MouseEntrez Gene 303241 RatEntrez Gene 1107 Human
  UniProt ID Q12873
• Background: This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.
• Synonyms: Mi-2a; Mi2-ALPHA; ZFH

Reference Data

• Protein Families: Druggable Genome