RANKL (TNFSF11) Mouse Monoclonal Antibody [Clone ID: 12A668]

CAT#: TA336377

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Mouse Monoclonal TRANCE/TNFSF11/RANK L Antibody (12A668)

Product Datasheet for 'TA336377'

USD 465.00

5 Days

    • 100 ug

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Product Data
Clone Name 12A668
Applications IHC, WB
Recommend Dilution WB: 0.5-2 ug/ml, FC: , IF: , IHC: 1:10-1:500, IHC-P: 5 ug/ml
Reactivity Human, Mouse, Rat
Host Mouse
Isotype IgG1, kappa
Clonality Monoclonal
Immunogen A bacterially expressed fusion protein containing amino acid residues 1-317 of mouse TRANCE was used as immunogen (NP_003692).
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration 0.5 mg/ml
Purification Protein G purified
Predicted Protein Size 35 kDa
Gene Name tumor necrosis factor superfamily member 11
Background TRANCE/OPGL/RANKL/ODF is a recently identified member of tumor necrosis factor family. TRANCE (TNF-related activation-induced cytokine receptor) or RANKL {receptor activator of NF-kB (RANK) ligand} has been implicated in interactions between T cells and dendritic cells. RANK ligand (RANKL/TRANCE) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. TRANCE/RANKL is also important in T and B-cell maturation. As OPGL/ODF (Osteoprotegerin Ligand/Osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis. OPGL/TRANCE deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis.
Note Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM sodium citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min.
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction
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