SMAD2 Rabbit Polyclonal Antibody

CAT#: TA336363

Rabbit Polyclonal Smad2 Antibody

Product Images

Western Blot: Smad2 Antibody TA336363 - Lysate from rat muscle in the 1) absence and 2) presence of immunizing peptide probed with this antibody at 3 ug/ml.

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  Immunohistochemistry-Paraffin: Smad2 Antibody TA336363 - Mouse testis tissue probed with this antibody at 5 ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry, Immunohistochemistry-Paraffin: 5 ug/ml, Western Blot: 2-4 ug/ml
• Reactivities: Human, Mouse, Rat, Bovine, Canine, Chicken, Primate
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Amino acids 234-249 (DQQLNQSMDTGSPAEL) of human SMAD2 protein was used as the immunogen.
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C. Do not freeze.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: SMAD family member 2
• Database Link:
  NP_001003652
  Entrez Gene 17126 MouseEntrez Gene 29357 RatEntrez Gene 4087 Human
  UniProt ID Q15796
• Background: SMAD2 is an intracellular protein belonging to the Dwarfin (DWA/B)/SMAD family. SMAD2 associates with SMAD4 for translocation to nucleus. It acts as an intracellular mediator of TGFbeta family of cytokines and activin type 1 receptor (ACVR1C). Hence it regulates multiple cellular processes like cell growth, proliferation, differentiation, and apoptosis and also cooperates with transcription factors to regulate expression of defined genes. Apart from playing an important role in TGFbeta1-induced CTGF expression they also act as markers of EMT in human PTECs. It also acts as an integrator of multiple signals in the regulation of NOS3 expression. It is ubiquitously expressed in most of the tissues and is responsible for colorectal, hepatocellular, lung and breast carcinomas as well as cervical cancer.
• Synonyms: hMAD-2; hSMAD2; JV18; JV18-1; MADH2; MADR2

Reference Data

• Protein Families: Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Stem cell relevant signaling - JAK/STAT signaling pathway, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transcription Factors
• Protein Pathways: Adherens junction, Cell cycle, Colorectal cancer, Pancreatic cancer, Pathways in cancer, TGF-beta signaling pathway, Wnt signaling pathway