Kcnmb4 Rabbit Polyclonal Antibody

CAT#: TA328959

Rabbit polyclonal Anti-slobeta4 (KCNMB4)

Product Images

Western blot analysis of rat brain membranes: 1. Anti-sloβ4 (KCNMB4) antibody, (1:200). 2. Anti-sloβ4 (KCNMB4) antibody, preincubated with the control peptide antigen.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:200-1:2000; IHC: 1:100-1:3000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide AKLRVSYEYTEAEDKS(C), corresponding to amino acid residues 2-17 of rat sloÃ?4. Intracellular, N-terminal part.
• Formulation: Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
• Reconstitution Method: Add 50 ul double distilled water (DDW) to the lyophilized powder.
• Purification: Affinity purified on immobilized antigen.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: potassium calcium-activated channel subfamily M regulatory beta subunit 4
• Database Link:
  NP_076450
  Entrez Gene 27345 HumanEntrez Gene 58802 MouseEntrez Gene 66016 Rat
  UniProt ID Q9ESK8
• Background: sloÃ?4 is a member of a family of regulatory b subunits that control the activity of the large conductance Ca2+-activated K+ channel KCa1.1. The family includes four members with a shared topology: two trans-membrane domains, short intracellular N- and C-termini and a large extracellular region.The four members of the family have a distinct tissue distribution with sloÃ?4 expressed almost exclusively in the central nervous sytem (CNS).Functionally, sloÃ?4 increases the sensitivity of the pore-forming KCa1.1 subunit to Ca2+ and voltage and it also changes its pharmacology. It has been shown that co-expression of sloÃ?4 with KCa1.1 makes the latter resistant to nM concentrations of the well-known inhibitors Charybdotoxin and Iberiotoxin.The physiological significance of sloÃ?4 expression in the CNS is not clear, but KCa1.1 channels are likely involved in the regulation of neurotransmitter release in presynaptic terminals.
• Synonyms: BKbeta4; Hbeta4; K(VCA)beta-4; Slo-beta-4