CD247 Mouse Monoclonal Antibody [Clone ID: 6B10.2]

CAT#: TA328059

Mouse Monoclonal anti-CD247 (TCR?, CD3?) Antibody

Product Images

Jurkat (1) and Raiji (2) cell extracts were resolved by electrophoresis, transferred to nitrocellulose and probed with purified anti-CD247 (TCR zeta, CD3 zeta) antibody. Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a chemiluminescence detection system.

Specifications

Product Data

• Clone Name: 6B10.2
• Applications: WB
• Recommended Dilution: WB, ICFC
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Immunogen: Human TCR zeta chain aa38-54
• Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
• Concentration: lot specific
• Purification: The antibody was purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: CD247 molecule
• Database Link:
  NP_932170
  Entrez Gene 919 Human
  UniProt ID P20963
• Background: The invariant TCR zeta chain is a member of the CD3 complex associated with the clonotypic alpha/beta TCR hetrodimer. The disulfide-linked TCRzeta homodimers transmit signals following TCR ligation. Loss of TCR zeta expression has been reported in a diverse range of disease states, including autoimmune diseases, many neoplastic conditions and chronic infections, such as tuberculosis and leprosy.
• Synonyms: CD3-ZETA; CD3H; CD3Q; CD3Z; IMD25; T3Z; TCRZ

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway