TdT (DNTT) Rabbit Polyclonal Antibody

CAT#: TA327743

Rabbit Polyclonal TdT Antibody

Product Images

Immunohistochemistry staining of Paraffin Thymus tissue by TdT antibody (dilution: 1:100 -1:500; visualization of staining: Nuclear)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 1:100 -1:500
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Formulation: This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: DNA nucleotidylexotransferase
• Database Link:
  NP_001017520
  Entrez Gene 1791 Human
  UniProt ID P04053
• Synonyms: TDT
• Note: TdT (Terminal deoxynucleotidyl transferase) gene is a member of the DNA polymerase type-X family and encodes a template- independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3’-hydroxyl terminus of oligonucleotide primers. TdT protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T-cell receptor gene segments.TdT expression occurs in over 90% of acute lymphoblastic lymphoma/leukemia cases with the exception of pre-B-cell ALL. TdT expression does not occur in normal mature T-or B-lymphocytes. Therefore, anti-TdT is a useful tool in diagnosis of T-ALL/ T-lymphoblastic lymphoma and B-ALL/B-lymphoblastic lymphoma. Anti-TdT labels Type B thymoma, thus it can be used as a diagnostic marker for this entity. Anti-TdT is positive for approximately one-third of all cases of chronic myeloid leukemia.

Reference Data

• Protein Pathways: Hematopoietic cell lineage, Non-homologous end-joining