CDX2 Rabbit Monoclonal Antibody [Clone ID: EPR2764Y]

CAT#: TA327657

Rabbit Monoclonal CDX2 Antibody

Product Images

Immunohistochemistry staining of Paraffin Colon tissue by CDX2 antibody (dilution: 1:100 - 1:500; visualization of staining: Nuclear)

Specifications

Product Data

• Clone Name: EPR2764Y
• Applications: IHC
• Recommended Dilution: IHC: 1:100 - 1:500
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Formulation: This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: caudal type homeobox 2
• Database Link:
  NP_001256
  Entrez Gene 1045 Human
  UniProt ID Q99626
• Synonyms: AS; CDX-3; CDX2; CDX3
• Note: CDX-2 is a caudal-related homeobox transcription factor whose expression in the adult is normally restricted to the intestinal epithelium. It is implicated in the development and maintenance of the intestinal mucosa. This protein is expressed immunohistochemically in the nuclei of normal intestinal epithelium. CDX-2 protein expression has been seen in gastrointestinal (GI) carcinomas, more so in lower GI than in upper GI. Anti-CDX-2 has been useful to establish gastrointestinal origin of metastatic adenocarcinomas and carcinoids and is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma. However, mucinous carcinomas of the ovary also stain positively with this antibody, which limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma versus mucinous carcinoma of the ovary.

Reference Data

• Protein Families: Adult stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Transcription Factors