PRMT2 Rabbit Polyclonal Antibody

CAT#: TA324182

Anti-PRMT2 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using TA324182 (PRMT2 Antibody) at dilution 1/20 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using TA324182 (PRMT2 Antibody) at dilution 1/20, treated with fusion protein. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA324182 (PRMT2 Antibody) at dilution 1/20 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA324182 (PRMT2 Antibody) at dilution 1/20, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human gastric cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 219-433 amino acids of human protein arginine methyltransferase 2
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: protein arginine methyltransferase 2
• Database Link:
  NP_996845
  Entrez Gene 3275 Human
  UniProt ID P55345
• Background: Protein arginine N-methyltransferase 2?is an?enzyme?that in humans is encoded by the?PRMT2?gene. Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3; FBL; histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR; PPARG; RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.
• Synonyms: HRMT1L1

Reference Data

• Protein Families: Druggable Genome