alpha 1b Adrenergic Receptor (ADRA1B) Rabbit Polyclonal Antibody

CAT#: TA323588

Anti-ADRA1B rabbit polyclonal antibody

Product Images

Gel: 8%SDS-PAGE Lysate: 80 μg Lane 1-3: 293T cells PC3 cells hela cells Primary antibody: TA323588 (ADRA1B Antibody) at dilution 1/500 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 2 minutes

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA323588 (ADRA1B Antibody) at dilution 1/25 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA323588 (ADRA1B Antibody) at dilution 1/25, treated with synthetic peptide. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA323588 (ADRA1B Antibody) at dilution 1/25 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA323588 (ADRA1B Antibody) at dilution 1/25, treated with synthetic peptide. (Original magnification: ×200)

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Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: 293T, PC3 and hela cells
  IHC: 25-100
  Positive control: Human liver cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 506-520 amino acids of human adrenoceptor alpha 1B
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 57 kDa
• Gene Name: adrenoceptor alpha 1B
• Database Link:
  NP_000670
  Entrez Gene 11548 MouseEntrez Gene 24173 RatEntrez Gene 147 Human
  UniProt ID P35368
• Background: Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.
• Synonyms: ADRA1; ALPHA1BAR

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction