Bcl x (BCL2L1) Rabbit Polyclonal Antibody

CAT#: TA323213

Anti-BCL2L1 Rabbit Polyclonal Antibody

Product Images

Gel: 12+15%SDS-PAGE Lysate: 40 μg Lane: Human cervical cancer tissue Primary antibody: TA323213 (BCL2L1 Antibody) at dilution 1/300 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 10 seconds

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Human cervical cancer tissue
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 1-210 amino acids of human BCL2-like 1
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 26 kDa
• Gene Name: BCL2 like 1
• Database Link:
  NP_001182
  Entrez Gene 12048 MouseEntrez Gene 24888 RatEntrez Gene 598 Human
  UniProt ID Q07817
• Background: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane; and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential; and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria; both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants; which encode distinct isoforms; have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.?
• Synonyms: Bcl-X; BCL-XL; BCL2L; BCLX; PPP1R52; S

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Amyotrophic lateral sclerosis (ALS), Apoptosis, Chronic myeloid leukemia, Jak-STAT signaling pathway, Pancreatic cancer, Pathways in cancer, Small cell lung cancer