Laminin alpha 5 (LAMA5) Rabbit Polyclonal Antibody

CAT#: TA322581

Anti-LAMA5 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TA322581 (LAMA5 Antibody) at dilution 1/8 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TA322581 (LAMA5 Antibody) at dilution 1/8, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 10-50
  Positive control: Human thyroid cancer
  Predicted cell location: Cytoplasm, Cell membrane
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 64-77 amino acids of Human laminin, alpha 5
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: laminin subunit alpha 5
• Database Link:
  NP_005551
  Entrez Gene 3911 Human
  UniProt ID O15230
• Background: Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular; the laminins; a family of heterotrimeric extracellular glycoproteins; affect tissue development and integrity in such diverse organs as the kidney; lung; skin; and nervous system. It is thought that laminins mediate the attachment; migration; and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha; beta; and gamma chains; with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene; but the full-length nature of one of them has not been determined.
• Synonyms: KIAA1907

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: ECM-receptor interaction, Focal adhesion, Pathways in cancer, Small cell lung cancer