VANGL2 Rabbit Polyclonal Antibody

CAT#: TA322268

Anti-VANGL2 Rabbit Polyclonal Antibody

Product Images

Gel: 10%SDS-PAGE Lysate: 40 μg Lane: NIH/3T3 cells Primary antibody: TA322268 (VANGL2 Antibody) at dilution 1/250 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 2 seconds

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  Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA322268 (VANGL2 Antibody) at dilution 1/15 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA322268 (VANGL2 Antibody) at dilution 1/15, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: NIH/3T3 cells
  IHC: 15-50
  Positive control: Human lung cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 20-34 amino acids of human vang-like 2 (van gogh, Drosophila)
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 60 kDa
• Gene Name: VANGL planar cell polarity protein 2
• Database Link:
  NP_065068
  Entrez Gene 93840 MouseEntrez Gene 289229 RatEntrez Gene 57216 Human
  UniProt ID Q9ULK5
• Background: The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity; especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. Plays a role in the regulation of planar cell polarity; particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process.
• Synonyms: LPP1; LTAP; STB1; STBM; STBM1

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Wnt signaling pathway