NAIF1 Rabbit Polyclonal Antibody

CAT#: TA321982

Anti-NAIF1 Rabbit Polyclonal Antibody

Product Images

Gel: 8%SDS-PAGE Lysate: 40 μg Lane: C2C12 cell lysate Primary antibody: TA321982 (NAIF1 Antibody) at dilution 1/1000 Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution Exposure time: 10 seconds

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  Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TA321982 (NAIF1 Antibody) at dilution 1/100 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TA321982 (NAIF1 Antibody) at dilution 1/100, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1000-5000
  WB positive control: C2C12 cell lysate
  IHC: 100-200
  Positive control: Human esophagus cancer
  Predicted cell location: Nucleus
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 18 kDa
• Gene Name: nuclear apoptosis inducing factor 1
• Database Link:
  NP_931045
  Entrez Gene 71254 MouseEntrez Gene 203245 Human
  UniProt ID Q69YI7
• Background: Human NAIF1 is located on chromosome 9q34.11 and encodes 327 amino acids with a homeodomain-like region and two nuclear localization signals at its N-terminal region. NAIF1 is conserved across diverse species; including human; mouse; crab-eating macaque; dog; chicken and frog; and shares no obvious homology to any known genes or proteins. NAIF1 was predominantly localized in the nucleus. Overexpression of NAIF1 inhibited cell growth and induced apoptosis. Furthermore; NAIF1 transfection caused both decreases in mitochondrial membrane potential and caspase-3 activation. In summary; NAIF1 is a nuclear protein that induces apoptosis when overexpressed.
• Synonyms: bA379C10.2; C9orf90