TIAF1 Rabbit Polyclonal Antibody

CAT#: TA319775

Rabbit Polyclonal TIAF Antibody

Product Images

Western blot analysis of TIAF in K562 cell lysate with TIAF antibody at 1 ug/mL.

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  Immunocytochemistry of TIAF in K562 cells with TIAF antibody at 2.5 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TIAF antibody was raised against a 16 amino acid peptide near the amino terminus of human TIAF .
• Formulation: TIAF Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: TIAF Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 13 kDa; Observed: 14 kDa
• Gene Name: TGFB1-induced anti-apoptotic factor 1
• Database Link:
  NP_004731
  Entrez Gene 9220 Human
  UniProt ID O95411
• Background: TIAF Antibody: TIAF-1 (TGFB1-induced anti-apoptotic factor 1), also known as MYO18A, is a TGFB1-induced anti-apoptotic factor that functions to inhibit the cytotoxic effects of TNF-alpha, TRADD and FADD. It localizes to the nucleus and significantly up-regulated in activated helper T lymphocytes (TH2) in chronic kidney and liver allograft rejection. Suppression of TIAF1 expression by siRNA prevents UV irradiation-mediated p53 phosphorylation and nuclear translocation. TIAF1 is essential in the p53- and WOX1-mediated cell death and shows an aggregation-dependent control of tumor progression and metastasis, and regulation of cell death.
• Synonyms: MAJN; SPR210

Reference Data

• Protein Families: Druggable Genome