Nephrin (NPHS1) Rabbit Polyclonal Antibody

CAT#: TA319690

Rabbit Polyclonal Nephrin Antibody

Product Images

Immunohistochemistry of Nephrin in human kidney tissue with Nephrin antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 5 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Nephrin antibody was raised against a 16 amino acid synthetic peptide from near the center of human Nephrin.
• Formulation: Nephrin Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Nephrin Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: NPHS1 nephrin
• Database Link:
  NP_004637
  Entrez Gene 4868 Human
  UniProt ID O60500
• Background: Nephrin Antibody: Nephrin is strongly expressed in renal glomeruli and is a member of the immunoglobulin family of cell adhesion molecules. Mutations in the Nephrin gene result in congenital nephrotic syndrome, an autosomal-recessive disorder characterized by massive proteinuria in utero and nephrosis at birth. Renal glomeruli allow normal kidneys to filter plasma so that it is very pure. Nephrin is expressed in the podocyte slit-diaphragm of the renal glomeruli in a manner that suggests that Nephrin molecules homodimerize in an anti-parallel fashion similar to cadherin interactions in adherens junctions. Thus, Nephrin may constitute the entire extracellular structure of the slit-diaphragm.
• Synonyms: CNF; nephrin; NPHN

Reference Data

• Protein Families: Druggable Genome, Transmembrane