MUM1 (IRF4) Rabbit Polyclonal Antibody

CAT#: TA319669

Rabbit Polyclonal IRF4 Antibody

Product Images

Western blot analysis of IRF4 in Jurkat cell lysate with IRF4 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunofluorescence of IRF4 in Jurkat cells with IRF4 antibody at 20 ug/mL.

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  Immunocytochemistry of IRF4 in Jurkat cells with IRF4 antibody at 10 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: IRF4 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human IRF4.
• Formulation: IRF4 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: IRF4 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: interferon regulatory factor 4
• Database Link:
  NP_002451
  Entrez Gene 3662 Human
  UniProt ID Q15306
• Background: IRF4 Antibody: Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. Another member, IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF4 expression is tightly regulated in resting primary T cells and plays an essential role in the homeostasis and function of mature lymphocytes. IRF4 is induced by Toll-like receptor (TLR) activation and acts as a negative regulator of TLR signaling.
• Synonyms: LSIRF; MUM1; NF-EM5; SHEP8