TIMP4 Mouse Monoclonal Antibody [Clone ID: 9:4-7]

CAT#: TA319578

Mouse monoclonal anti-TIMP4 antibody

Product Images

Immunohistochemistry of Mouse Anti-TIMP4 Antibody. Tissue: human breast carcinoma. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: a) isotype specific IgG2bk monoclonal; b) TIMP-4 antibody (clone 9:4-7); and c) TIMP-4 each at 10 ug/mL. Secondary antibody: Peroxidase mouse secondary antibody at 1:10,000 for 45 min at RT. Localization: TIMP-4 is secreted. Staining: TIMP-4 as precipitated brown signal.

Specifications

Product Data

• Clone Name: 9:4-7
• Applications: IHC
• Recommended Dilution: ELISA: 1:20,000 to 1:100,000, WB: 1:2,000 to 1:10,000, IHC: 5-10ug/mL
• Reactivities: Human, Mouse
• Host: Mouse
• Clonality: Monoclonal
• Immunogen: Anti-TIMP4 (MOUSE) Monoclonal Antibody was produced in mouse by repeated immunizations with full legnth human TIMP4 protein followed by hybridoma development.
• Formulation: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: TIMP metallopeptidase inhibitor 4
• Database Link:
  NP_003247
  Entrez Gene 110595 MouseEntrez Gene 7079 Human
  UniProt ID Q99727
• Synonyms: TIMP metallopeptidase inhibitor 4; tissue inhibitor of metalloproteinase 4
• Note: Tissue inhibitor of metalloproteinase-4 (TIMP-4) is member of the TIMP family of inhibitors of matrix metalloproteinase (MMP) activities. In addition, TIMPs have non-MMP associated functions, including roles in growth promotion, apoptosis, and angiogenesis. All four members of the TIMP gene family form a similar secondary structure due to the formation of six highly conserved disulfide bonds. It has been reported that some TIMPs, TIMP4 included, can bind a tetraspanin in the plasma membrane, initiating an intra-cellular signaling cascade. Elevated levels of TIMP4 have been associated with breast cancer progression and heart disease.

Reference Data

• Protein Families: Druggable Genome, Secreted Protein