Progesterone Receptor (PGR) Mouse Monoclonal Antibody [Clone ID: 608]

CAT#: TA309221

mouse Anti-Progesterone Receptor (Ser294) Antibody (Phospho-Specific)

Product Images

Western blot of whole cell T47D lysate prepared from cells that had been incubated in the presence of the synthetic progestin agonist [R5020] (500 nM) showing specific immunolabeling of the ~90k PR-A isoform and the ~120 PR-B isoform of the progesterone receptor phosphorylated at Ser294. The immunolabeling is blocked by the phosphopeptide used as the antigen (not shown).

Specifications

Product Data

• Clone Name: 608
• Applications: WB
• Recommended Dilution: WB: 1:1000, IHC: 1:1000
• Reactivities: Human
• Modifications: Phospho-specific
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser294 conjugated to KLH
• Formulation: 100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 90/120 kDa
• Gene Name: progesterone receptor
• Database Link:
  NP_000917
  Entrez Gene 5241 Human
  UniProt ID P06401
• Background: This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq]
• Synonyms: NR3C3; PR

Reference Data

• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
• Protein Pathways: Oocyte meiosis, Progesterone-mediated oocyte maturation