Thymidylate Synthase (TYMS) Rabbit Polyclonal Antibody

CAT#: TA308802

Rabbit polyclonal antibody to Thymidylate synthetase (thymidylate synthetase)

Product Images

Sample (30 ug of whole cell lysate). A: H1299. 10% SDS PAGE. TA308802 diluted at 1:1000.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB:1:500-1:3000
• Reactivities: Human (Predicted: Mouse, Monkey, Pig, Rat, Zebrafish, X. tropicalis)
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 122 and 313 of Thymidylate synthetase (Uniprot ID#P04818)
• Formulation: 1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 36 kDa
• Gene Name: thymidylate synthetase
• Database Link:
  NP_001062
  Entrez Gene 22171 MouseEntrez Gene 29261 RatEntrez Gene 697580 MonkeyEntrez Gene 7298 Human
  UniProt ID P04818
• Background: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq]
• Synonyms: HST422; TMS; TS
• Note: Seq homology of immunogen across species: Mouse (94%), Monkey (98%), Pig (96%), Rat (95%), Zebrafish (87%), Xenopus tropicalis (85%)

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, One carbon pool by folate, Pyrimidine metabolism