Ataxin 3 (ATXN3) Rabbit Polyclonal Antibody

CAT#: TA308320

Rabbit Polyclonal antibody to Ataxin 3 (ataxin 3)

Product Images

Ataxin 3 antibody detects Ataxin 3 protein by western blot analysis. Mouse tissue extracts (50 ug) was separated by 10 % SDS-PAGE, and blotted with Ataxin 3 antibody (TA308320) diluted by 1:500

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  Ataxin 3 antibody detects Ataxin 3 protein by western blot analysis. 293T mock transfected (-) or transfected with a construct expressing human Ataxin 3 (+). 10 % SDS-PAGE. Ataxin 3 antibody (TA308320) dilution: 1:5000

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  Immunohistochemical analysis of paraffin-embedded H661 xenograft, using Ataxin 3 (TA308320) antibody at 1:500 dilution.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: IHC:1:100-1:1000; WB:1:500-1:10000
• Reactivities: Human, Mouse (Predicted: Pig, Rat, Bovine)
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 245 of Ataxin 3 (Uniprot ID#P54252)
• Formulation: 1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 42 kDa
• Gene Name: ataxin 3
• Database Link:
  NP_001121169
  Entrez Gene 60331 RatEntrez Gene 110616 MouseEntrez Gene 4287 Human
  UniProt ID P54252
• Background: Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]
• Synonyms: AT3; ATX3; JOS; MJD; MJD1; SCA3
• Note: Seq homology of immunogen across species: Pig (99%), Rat (96%), Bovine (98%)

Reference Data

• Protein Families: Druggable Genome, Transcription Factors