C16orf5 (CDIP1) Rabbit Polyclonal Antibody

CAT#: TA306735

Rabbit Polyclonal CDIP Antibody

Product Images

Western blot analysis of CDIP in human brain lysate with CDIP antibody at (A) 0.25 and (B) 0.5 ug/mL.

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  Immunohistochemistry of CDIP in mouse brain tissue with CDIP antibody at 2.5 ug/mL.

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  Immunofluorescence of CDIP1 in mouse brain tissue with CDIP1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.25 - 0.5 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CDIP antibody was raised against a 19 amino acid peptide near the center of human CDIP.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: cell death-inducing p53 target 1
• Database Link:
  NP_037531
  Entrez Gene 66626 MouseEntrez Gene 29965 Human
  UniProt ID Q9H305
• Background: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induced apoptosis in transfected cells while siRNA suppression of caspase-8 mRNA blocked this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through extrinsic cell death pathway. CDIP may thus represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.
• Synonyms: C16orf5; CDIP; I1; LITAFL

Reference Data

• Protein Families: Transmembrane