ZIP Kinase (DAPK3) Rabbit Polyclonal Antibody

CAT#: TA305981

Rabbit Polyclonal ZIPK Antibody

Product Images

Western blot analysis of ZIP kinase in HeLa (H) and Jurkat (J) whole cell lysates with ZIP kinase antibody at 1 ug/mL.

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  Immunofluorescence of ZIPK in Jurkat cells with ZIPK antibody at 10ug/ml.

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  Immunocytochemistry of ZIPK in Jurkat cells with ZIPK antibody at 5ug/ml.

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  Immunofluorescence of ZIPK in Jurkat cells with ZIPK antibody at 5ug/ml.

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  Immunofluorescence of ZIPK in Jurkat cells with ZIPK antibody at 10ug/ml.

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  Immunocytochemistry of ZIPK in Jurkat cells with ZIPK antibody at 10ug/ml.

• Immunocytochemistry of ZIP kinase in Jurkat cells with ZIP kinase antibody at 10ug/ml.

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Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 10 ug/mL, IF: 10 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ZIP kinase antibody was raised against a peptide corresponding to amino acids near the center of human ZIP kinase. The immunogen is located within amino acids 270 - 320 of ZIPK.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: death associated protein kinase 3
• Database Link:
  BAA81746
  Entrez Gene 1613 Human
  UniProt ID O43293
• Background: Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. A novel serine/threonine kinase that mediates apoptosis was recently identified and designated ZIP kinase . ZIP kinase contains an N-terminal kinase domain and a C-terminal leucine zipper structure and binds to ATF4 that is a member of ATF/CREB family. ZIP kinase has high sequence homology to DAP kinase (death-associated protein kinase), which is a mediator of apoptosis induced by gamma interferon. Overexpression of ZIP kinase induces apoptosis. ZIP and DAP kinases represent a novel kinase family, which mediates apoptosis through their catalytic activities. The messenger RNA was ubiquitously expressed in various tissues .
• Synonyms: DLK; ZIP; ZIPK