GAD67 (GAD1) (+ GAD2 / GAD65) Rabbit Polyclonal Antibody

CAT#: SP1218P

GAD67 (GAD1) (+ GAD2 / GAD65) rabbit polyclonal antibody, Purified

USD 1,040.00

5 Days*

    • 100 ul

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Product Data
Applications ELISA, IHC, WB
Recommended Dilution ELISA.
Western Blot: 1/1000-1/10000.
Immunohistochemistry on Frozen Sections: 1/200-1/5000.
Recommended Positive Control: Brain.
Reactivities Feline, Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide sequence from the C-terminus of GAD
Specificity This antibody recognises both molecular forms of Glutamic Acid Decarboxylase (GAD65 and GAD67), the enzyme which converts glutamic acid to gamma -aminobutyric acid (GABA), the major inhibitory transmitter in the higher brain region.
Formulation PBS containing 0.09% Sodium Azide as preservative and 1% BSA as stabilizer.
State: Purified
State: Liquid purified Immunoglobulin-rich fraction.
Purification Ammonium Sulphate Precipitation.
Conjugation Unconjugated
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name glutamate decarboxylase 1
Background This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma aminobutyric acid from L glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin dependent diabetes. This gene may also play a role in the stiff man syndrome.
Synonyms Glutamate decarboxylase 1, GAD-67
Note Predicted Molecular Weight: 65 and 67 kDa.
Reference Data
Protein Families Druggable Genome
Protein Pathways Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Butanoate metabolism, Metabolic pathways, Taurine and hypotaurine metabolism, Type I diabetes mellitus

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.