CD8A Mouse Monoclonal Antibody [Clone ID: CT6]

CAT#: SM581

CD8A mouse monoclonal antibody, clone CT6, Supernatant

Specifications

Product Data

• Clone Name: CT6
• Applications: FC, IHC
• Recommended Dilution: Immunohistochemistry on Frozen Sections: 1/100.
  Flow Cytometry: Use 10 µl of 1/100 diluted antibody to label 10e6 lymphocytes in 100 µl.
• Reactivities: Guinea Pig
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Peritoneal T-cells.
• Specificity: Mouse anti Guinea Pig CD8 antibody, clone CT6 reacts with guinea pig CD8 present on cytotoxic T-cells. CD 8 comprises 2 subunits, alpha and beta and exists as either an alpha/alpha homodimer or an alpha/beta heterodimer. Sequence suggests that guinea pig CD8 is more closely related to human than rat or mouse CD8 (Nagarajan et al. 2004)
• Formulation: State: Supernatant
  State: Concentrated Tissue Culture Supernatant with 0.09% Sodium Azide and 0.7% BSA
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: CD8a molecule
• Database Link:
  Entrez Gene 925 Human
  UniProt ID P01732
• Background: The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.
• Synonyms: CD8 alpha chain, CD8A, MAL

Reference Data

• Protein Families: Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane
• Protein Pathways: Antigen processing and presentation, Cell adhesion molecules (CAMs), Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway