CD47 Mouse Monoclonal Antibody [Clone ID: MEM-122]
Other products for "CD47"
Specifications
Product Data | |
Clone Name | MEM-122 |
Applications | FC, IHC, WB |
Recommended Dilution | Flow cytometry: Recommended dilution: 1-4 μg/ml. Western blotting: Non-reducing conditions. |
Reactivities | Human, Porcine |
Host | Mouse |
Isotype | IgM |
Clonality | Monoclonal |
Immunogen | COS-7 (African green monkey) cells. |
Specificity | The antibody reacts with CD47 (Integrin Associated Protein), a 50-55 kDa membrane adhesion molecule (Thrombospondin Receptor; immunoglobulin supergene family) expressed on leukocytes, platelets and erythrocytes. It is also expressed on epithelial cells, endothelial cells, fibroblasts and many tumor cell lines. |
Formulation | PBS, pH~7.4 State: Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) Preservative: 15 mM Sodium Azide |
Concentration | lot specific |
Purification | CHT-Chromatography and Precipitation Methods |
Conjugation | Unconjugated |
Storage | Store the antibody undiluted at 2-8°C. DO NOT FREEZE! |
Stability | Shelf life: one year from despatch. |
Gene Name | CD47 molecule |
Database Link | |
Background | CD47 is an ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins. Binding secreted thrombospondin-1, CD47 counteracts graft vascularization. CD47 acts also as a ligand for CD172a (signal regulatory protein a, SIRPa), an immune inhibitory receptor on macrophages; this interaction prevents phagocytosis of CD47-positive cells. Moreover, CD47-CD172a system affects cell migration, B cell adhesion and T cell activation. CD47 is also involved in modulation of chondrocyte responses to mechanical signals, and promotes neuronal development, being especially abundant in synapse-rich regions of brain and retina. |
Synonyms | MER6, IAP, OA3 |
Reference Data |
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