B7-1 (CD80) Mouse Monoclonal Antibody [Clone ID: MAB104]

CAT#: DDX0160P-100

B7-1 (CD80) mouse monoclonal antibody, clone MAB104

Specifications

Product Data

• Clone Name: MAB104
• Applications: FC, FN
• Recommended Dilution: FACS, cell culture.
  Studies of ligand/receptor interactions Cell adhesion molecule Signal transduction in T-B interaction Dendritic cells activation.
  
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Jijoye cells (human Burkitt’s lymphoma cell line).
• Specificity: Human CD80.
• Formulation: State: Purified
  State: 100 μg in 200 μl / 50 μg in 100 μl Tris-NaCl pH 8
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: -20°C. KEEP CONTENTS STERILE: no preservative.
  Purified antibodies: avoid repeated freeze/thaw cycles.
  Coupled antibodies: glycerol protects from freezing.
• Gene Name: CD80 molecule
• Database Link:
  Entrez Gene 941 Human
  UniProt ID P33681
• Background: The CD80 antigen (B7, BB1) recognizes a 60 kDa transmembrane glycoprotein, member of the immunoglobulin family. This molecule shares with CD86 the capability to be the ligand for two structurally similar molecules expressed on T lymphocytes, CD28 and CD152 (CTLA-4). CD80 antigen is expressed on in vitro activated B lymphocytes. It is not expressed on the majority of resting B cells from peripheral blood but identifies a subpopulation of B cells that has been previously activated. The antigen is also expressed by HTLV-1 transformed T cells activated monocytes, and constitutively on dendritic cells. CD80 binding provides costimulatory signals for T cell activation.
  (Vallé A. et al, 1990; Immunology, 69:531-535; Freeman GJ. et al, 1992; Blood, 79:489-494).
• Synonyms: CD28LG, CD28LG1, LAB7, BB1, B7.1, B7-1