PSMD2 Mouse Monoclonal Antibody [Clone ID: OTI1G6]

CAT#: CF503217

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Carrier-free (BSA/glycerol-free) PSMD2 mouse monoclonal antibody, clone OTI1G6 (formerly 1G6)



  View other "OTI1G6" antibodies (5)

USD 600.00


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In Stock

Size
    • 100 ug


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Specifications

Product Data
Clone Name OTI1G6
Applications IF, IHC, WB
Recommended Dilution WB 1:500~2000, IHC 1:150, IF 1:100
Reactivities Human, Monkey, Mouse, Rat, Dog
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Full length human recombinant protein of human PSMD2(NP_002799) produced in HEK293T cell.
Formulation Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 100 kDa
Gene Name Homo sapiens proteasome 26S subunit ubiquitin receptor, non-ATPase 2 (PSMD2), transcript variant 1, mRNA.
Background The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. [provided by RefSeq]
Synonyms P97; RPN1; S2; TRAP2
Reference Data
Protein Families Druggable Genome
Protein Pathways Proteasome

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