VC1456 Rabbit Polyclonal Antibody

CAT#: BP1011

VC1456 rabbit polyclonal antibody, Ig Fraction

Specifications

Product Data

• Applications: ELISA, IF, IHC, IP
• Recommended Dilution: ELISA.
  Immunoprecipitation.
  Has been described to work in Immunohistochemistry on Frozen Sections and Immunofluorescence.
• Reactivities: Bacteria
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Purified choleragenoid
• Specificity: Reacts with the beta subunit of Cholera Toxin.
• Formulation: PBS, pH 7.2 containing 0.09% Sodium Azide as preservative.
  State: Ig Fraction
  State: Liquid purified Ig fraction.
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  UniProt ID P01556
• Background: The beta subunit of cholera toxin binds to a GM1-anglioside receptor which is widely accepted to initiate toxin action by triggering uptake and delivery of the toxin alpha subunit into cells. The holotoxin consists of a pentameric ring of beta subunits whose central pore is occupied by the alpha subunit. The alpha subunit contains two chains, A1 and A2, linked by a disulfide bridge. The alpha subunit (and cholera toxin) activate the adenylate cyclase enzyme in cells of the intestinal mucosa leading to increased levels of intracellular cAMP.
• Synonyms: Cholera enterotoxin B chain, Cholera enterotoxin gamma chain, Choleragenoid, ctxB, toxB, VC_1456