Cardiac Troponin I (TNNI3) (+ skeletal) Mouse Monoclonal Antibody [Clone ID: C5]

CAT#: BM748X

Cardiac Troponin I (TNNI3) (+ skeletal) mouse monoclonal antibody, clone C5, Purified

Specifications

Product Data

• Clone Name: C5
• Applications: ELISA, WB
• Reactivities: Amphibian, Bovine, Chicken, Fish, Human, Mouse, Rabbit
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Free human cardiac troponin I
• Specificity: This antibody reacts equally with free cardiac Troponin I (cTnI) and cTnI forming complexes with other troponin components. Not affected by heparin, phosphorylation and oxidation. Recognizes an epitope located between amino acid residues 186 and 192 of cTnI. Cross-reacts with skeletal troponin I from human, rat and mouse.
• Formulation: PBS, pH 7.4 containing 0,09% sodium azide
  State: Purified
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: >90% pure (SDS-PAGE). Protein A chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C.
  DO NOT FREEZE!
• Stability: Shelf life: one year from despatch.
• Gene Name: troponin I3, cardiac type
• Database Link:
  Entrez Gene 7137 Human
  UniProt ID P19429
• Background: Troponin I is part of a heteromeric complex playing an important role in the regulation of skeletal and cardiac muscle contraction. It consists of three subunits, troponin I (TnI), troponin T (TnT) and troponin C (TnC). Each subunit is responsible for part of troponin complex function. TnI inhibits ATPase activity of acto myosin and TnT and TnI are present in cardiac muscles in different forms than in skeletal muscles. Only one tissue specific isoform of TnI is described for cardiac muscle tissue (cTnI) and this is expressed only in myocardium.
• Synonyms: TNNI3, TNNC1