K Cadherin (CDH6) Mouse Monoclonal Antibody [Clone ID: 2B6]

CAT#: BM5097

K Cadherin (CDH6) mouse monoclonal antibody, clone 2B6, Supernatant

Specifications

Product Data

• Clone Name: 2B6
• Applications: IHC
• Recommended Dilution: Immunohistochemistry on frozen sections: paraformaldehyde fixed; with 0.2% Triton X-100 in PBS; Ready to use; 1 h at room temperature / overnight at 2-8°C.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: GST fusion protein of part of the extracellular domain of cadherin 6 (K-Cadherin).
• Specificity: This antibody reacts to Cadherin 6.
• Formulation: State: Supernatant
  State: Liquid Culture supernatant contains 0.1% sodium azide
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: cadherin 6
• Database Link:
  Entrez Gene 1004 Human
  UniProt ID P55285
• Background: The cadherin gene family encodes calcium-dependent adhesion molecules that promote homophilic interactions among cells. All cadherins are single-pass transmembrane proteins with a variable number of extracellular domains (EC; 110 amino acids long). Classical cadherins consist of five EC domains and a conserved cytoplasmic domain and are divided in type I and type II subgroups. Type I comprises cadherin E, N, P, and R. Type II include cadherin-5, -6, -8, -11, and -12. During embryogenesis differential expression of cadherins can drive morphogenesis by stimulating cell aggregation, defining boundaries between groups of cells and promoting cell migration. Cadherin-6 seems to be required for the early aggregation of induced mesenchymal cells and their subsequent conversion to epithelium.
• Synonyms: CDH6, Kidney cadherin, Cadherin K, K-Cadherin