Insulin (INS) (+Proinsulin) Mouse Monoclonal Antibody [Clone ID: D3E7 (5B6/6)]

CAT#: BM508

Insulin (INS) (+Proinsulin) mouse monoclonal antibody, clone D3E7 (5B6/6), Purified

Product Images

Staining of Paraffin Embedded Human pancreas with Mouse anti Rat Insulin Antibody (Clone D3E7)

Specifications

Product Data

• Clone Name: D3E7 (5B6/6)
• Applications: ELISA, IHC
• Recommended Dilution: ELISA: This antibody is suitable for use as a Detection antibody with BM507 as the Capture antibody.
  Immunohistochemistry on Frozen Sections (Ref.1).
  Immunohistochemistry on Paraffin Sections: 1/100-1/300.
• Reactivities: Bovine, Human, Mouse, Porcine, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Human Insulin.
• Specificity: This antibody recognizes both Insulin and Proinsulin, but does not react with free C-Peptide.
• Formulation: PBS
  State: Purified
  State: Liquid purified IgG fraction
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: insulin
• Database Link:
  Entrez Gene 3630 Human
  UniProt ID P01308
• Background: Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Immunocytochemical investigations have localized insulin in the B cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B cell origin such as insulinoma.
• Synonyms: INS

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
• Protein Pathways: Insulin signaling pathway, Maturity onset diabetes of the young, mTOR signaling pathway, Oocyte meiosis, Progesterone-mediated oocyte maturation, Prostate cancer, Regulation of actin cytoskeleton, Regulation of autophagy, Type I diabetes mellitus, Type II diabetes mellitus