SREBP1 (SREBF1) pSer439 Rabbit Polyclonal Antibody

CAT#: AP55903PU-N

SREBP1 (SREBF1) pSer439 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of extracts from Jurkat cells treated with TNF using Phospho-SREBP-1 (Ser439) antibody.The lane on the right is treated with the antigen-specific peptide.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1:500~1:1000.
• Reactivities: Human, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide sequence around phosphorylation site of serine439(Q-S-S(p)-P-L) derived from Human SREBP-1 (KLH-conjugated)
• Specificity: The antibody detects endogenous level of SREBP-1 only when phosphorylated at serine 439.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography using epitope-specific peptide
• Conjugation: Unconjugated
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 122 kDa
• Gene Name: sterol regulatory element binding transcription factor 1
• Database Link:
  Entrez Gene 6720 Human
  UniProt ID P36956
• Background: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway By similarity. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').
• Synonyms: SREBP-1, BHLHD1