DRP1 (DNM1L) pSer637 Rabbit Polyclonal Antibody

CAT#: AP55855PU-N

DRP1 (DNM1L) pSer637 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of extracts from JK cells and K562 cells using DRP1 (Phospho-Ser637) Antibody.The lane on the right is treated with the antigen-specific peptide.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1:500~1:1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide sequence around phosphorylation site of Serine637(K-L-S(p)-A-R) derived from Human DRP1 (KLH-conjugated)
• Specificity: The antibody detects endogenous levels of DRP1 only when phosphorylated at serine 637.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography using epitope-specific peptide
• Conjugation: Unconjugated
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 82 kDa
• Gene Name: dynamin 1-like
• Database Link:
  Entrez Gene 10059 Human
  UniProt ID O00429
• Background: Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation.
• Synonyms: DNM1L, DLP1, DRP1, Dynamin-like protein, Dnm1p/Vps1p-like protein, HdynIV