CCR5 pSer349 Rabbit Polyclonal Antibody

CAT#: AP55693PU-S

CCR5 pSer349 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of extracts from A549 cells (Lane 2), using CCR5 (Phospho-Ser349) Antibody. The lane on the left is treated with antigen-specific peptide.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1:500~1:1000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide sequence around phosphorylation site of Serine 349 (E-I-S(p)-V-G) derived from Human CCR5 (KLH-conjugated)
• Specificity: The antibody detects endogenous levels of CCR5 only when phosphorylated at serine 349.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography using epitope-specific peptide
• Conjugation: Unconjugated
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 40 kDa
• Gene Name: C-C motif chemokine receptor 5 (gene/pseudogene)
• Database Link:
  Entrez Gene 1234 Human
  UniProt ID P51681
• Background: Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.
• Synonyms: C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CMKBR5, CHEMR13