CACNA1S (alpha-1) Rabbit Polyclonal Antibody

CAT#: AP55388SU-N

CACNA1S (alpha-1) rabbit polyclonal antibody, Serum

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Western Blot: 1/200-1/2000.
  Immunohistochemistry: 1/50-1/500.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide derived from C-term domain of Cav1.1 protein
• Specificity: Reacts with Human 212 kDa protein.
  May cross react with CAC1S proteins from Rat, Mouse and other species du to homology sequences.
• Formulation: State: Serum
  State: Lyophilized powder
  Preservative: None
• Reconstitution Method: Restore in distilled water
• Conjugation: Unconjugated
• Storage:

  Prior to reconstitution store the antibody at -20°C.
  Store reconstituted antibody at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: calcium voltage-gated channel subunit alpha1 S
• Database Link:
  Entrez Gene 779 Human
  UniProt ID Q13698
• Background: Voltage-sensitive calcium channels mediate the entry of calcium into many types of excitable cells and thus play a key role in neurotransmitter release and excitation-contraction (E-C) coupling. The 1,4-dihydropyridines (DHPs) are synthetic organic compounds which can be used to identify the L-type calcium channels that are found in all types of vertebrate muscle, neuronal and neuroendocrine cells. The DHP receptor is part of the L-type calcium channel complex and is thought to be the voltage sensor in E-C coupling.The purified DHP receptor isolated from triads is composed of at least four subunits. The alpha-1 subunit contains the binding site for the DHPs and shows high sequence homology to the voltage gated sodium channel. The alpha-2 subunit is a large glycoprotein associated with the DHP receptor which was first described in skeletal muscle and is also found in high concentrations in other excitable tissues such as cardiac muscle and brain and in low concentrations in most other tissues studied. The other two subunits that co-purify with the DHP receptor are termed beta and gamma.
• Synonyms: CACH1, CACN1, CACNL1A3, Cav1.1