VANGL1 Rabbit Polyclonal Antibody

CAT#: AP55374SU-N

VANGL1 rabbit polyclonal antibody, Serum

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution:

  ELISA.
  Western Blot: 1/500-1/5000.
  Immunohistochemistry: 1/100-1/500.

• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide derived from N-terminal domain of Human VANGL1
• Specificity: Reacts with Human 60 kDa VANGL1 protein.
  Cross reacts with Mouse.
• Formulation: State: Serum
  State: Lyophilized powder
  Preservative: None
• Reconstitution Method: Restore in distilled water.
• Conjugation: Unconjugated
• Storage:

  Prior to reconstitution store the antibody at -20°C.
  Store reconstituted antibody at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: VANGL planar cell polarity protein 1
• Database Link:
  Entrez Gene 81839 Human
  UniProt ID Q8TAA9
• Background: Vang-like 1 protein is a novel human homologue of Drosophila Van Gogh/Strabismus. The Vang-like 1 gene consists of at least 7 exons, and encodes a protein with four transmembrane domains and the C-terminal Ser/Thr-X-Val motif. Studies shows that the expression of the protein is significantly up-regulated in gastric cancer cell lines MKN28, MKN74, pancreatic cancer cell lines BxPC-3, PSN-1 and Hs766T. The protein may serve as an effector mediating the intestinal trefoil factor (ITF) healing response of the intestinal mucosa. The protein also serves as a diagnostic marker for hepatocellular carcinoma as well as a potential molecular target for development of novel therapeutic drugs. The pathological role of the protein has been identified in neural tube defects (NTD). Human Vang-like 1 gene maps to chromosome 1p11-p13.1.
• Synonyms: Van Gogh-like protein 1, Strabismus 2, STB2, LPP2