SEMA4A (N-term) Rabbit Polyclonal Antibody

CAT#: AP53846PU-N

SEMA4A (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of SEMA4A Antibody (N-term) in Mouse kidney tissue lysates (35ug/lane). This demonstrates the SEMA4A antibody detected the SEMA4A protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/100-1/500.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 150-180 amino acids from the N-terminal region of Human SEMA4A
• Specificity: Recognizes SEMA4A (N-term).
• Formulation: PBS with 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column followed by peptide Affinity purification
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: semaphorin 4A
• Database Link:
  Entrez Gene 20351 MouseEntrez Gene 64218 Human
  UniProt ID Q9H3S1
• Background: This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
• Synonyms: Semaphorin-4A, Semaphorin-B, Sema B, SEMAB, SEMB
• Note: Molecular Weight: 83574 Da

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Axon guidance