hHR23b (RAD23B) (N-term) Rabbit Polyclonal Antibody

CAT#: AP53559PU-N

hHR23b (RAD23B) (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of RAD23B Antibody (N-term) in A549 cell line lysates (35ug/lane). This demonstrates the RAD23B antibody detected the RAD23B protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 10-40 amino acids from the N-terminal region of Human RAD23B.
• Specificity: This antibody recognizes Human RAD23B (N-term).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: RAD23 homolog B, nucleotide excision repair protein
• Database Link:
  Entrez Gene 5887 Human
  UniProt ID P54727
• Background: The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.
• Synonyms: HR23B
• Note: Molecular Weight: 43171 Da

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Nucleotide excision repair