PTPN22 (C-term) Rabbit Polyclonal Antibody

CAT#: AP53511PU-N

PTPN22 (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis in NCI-H460 cell line lysates (35ug/lane) using PTPN22 antibody. (C-term). This demonstrates the PTPN22 antibody detected the PTPN22 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution:

  Western blot: 1/100-1/500.
  Enzyme immunoassay: 1/1000.

• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 662-691aa) of human PTPN22.
• Specificity: This antibody recognizes PTPN22 at C-term.
• Formulation: PBS with 0.09% (W/V) Sodium azide
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Purified through a Protein A column followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: protein tyrosine phosphatase, non-receptor type 22
• Database Link:
  Entrez Gene 26191 Human
  UniProt ID Q9Y2R2
• Background: The PTPN22 gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.
• Synonyms: PTPN8, Lymphoid phosphatase, LyP, LYP1, LYP2, PEP
• Note: Molecular Weight: 91705 Da

Reference Data

• Protein Families: Druggable Genome, Phosphatase