DNA Ligase I (LIG1) (N-term) Rabbit Polyclonal Antibody

CAT#: AP52477PU-N

DNA Ligase I (LIG1) (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of DNA liage 1 Antibody (N-term) ( in CEM cell line lysates (35ug/lane).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of Human DNA ligase 1
• Specificity: This antibody recognizes Human DNA ligase 1 (N-term).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: DNA ligase 1
• Database Link:
  Entrez Gene 3978 Human
  UniProt ID P18858
• Background: LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents.
• Synonyms: LIG1, LIG-1, DNA ligase 1, EC=6.5.1.1, DNA ligase I
• Note: Molecular Weight: 101736 Da

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Base excision repair, DNA replication, Mismatch repair, Nucleotide excision repair